Elevated Adaptive Immune Responses Are Associated with Latent Infections of Wuchereria bancrofti

Elevated Adaptive Immune Responses Are Associated with Latent Infections of Wuchereria bancrofti

In order to guarantee the fulfillment of their complex lifecycle, adult filarial nematodes release millions of microfilariae (MF), which are taken up by mosquito vectors. The current strategy to eliminate lymphatic filariasis as a public health problem focuses upon interrupting this transmission through annual mass drug administration (MDA). It remains unclear however, how many rounds of MDA ar...

Transmission of Wuchereria Bancrofti

me about the mode of transmission of Wuchereria bancrojti. I understood that it was through the bite of an infected mosquito (Culex) larva passing through the bite puncture though capable of penetrating the healthy skin. I have just read in the ' Science and Practice of, Surgery', 1948 ed. (vol. I, p. 258) by Romanis and Mitchiner, that the infection is through drinking water in which the bodie...

Lectin-binding characteristics of Wuchereria bancrofti microfilariae.

The binding of 10 different lectins to the surface of microfilariae of Wuchereria bancrofti has been investigated. Wheat germ agglutinin (WGA) and Helix pomatia lectin (HPA) bound specifically to the sheathed microfilariae indicating the presence of N-acetyl-D-glucosamine and N-acetyl-D-galactosamine respectively on the surface. Exsheathed microfilariae did not react with any of the lectins. Tr...

An unusual presentation of Wuchereria bancrofti infection.

Prevalence of Wuchereria bancrofti in Georgetown, Guyana1

A random sample bloodsmear survey was conducted during evening hours in Georgetown, Guyana, to determine the prevalence of Wuchereria bancrofti microfilariae. In all, 182 of 2,818 persons tested (6.5%) yielded positive results-indicating that the overall prevalence of Bancroffian filariasis has not diminished and may be on the rise. Relatively high prevalences found in children and adolescents ...